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prof. dr. G. (Gerard) Pasterkamp

Full Professor

  • Department of Clinical Chemistry and Haematology

prof. dr. G. (Gerard) Pasterkamp

Research Programs

Biography

Gerard Pasterkamp, MD, is professor Experimental Cardiology and scientific medical manager of the division LAB. UMC Utrecht. His research interests are in the field of cardiovascular biology and more specifically innovation in biomarkers. His research interests are in the field of cardiovascular biology and innovation in biomarkers and drug targets. The research group houses the largest atherosclerotic plaque biobank worldwide: Athero Express including >4000 patients. This biobank has generated new insights into determinants of plaque destabilisation. The laboratory also invests in the excavation of genetic determinants of atherosclerotic plaque characteristics. He coordinates national and EU based consortia with the aim to unravel biomarkers and mechanisms of atherosclerotic disease. His translational profile is noted in the private public consortia he is involved in. He is supervising three public private grants that have been rewarded with the aim to develop novel biomarkers and imaging technology to detect cardiac ischemia and endothelial dysfunction. In 2018 he obtained a LeDucq grant together with Prof G Owens (Virginia University) on the role of smooth muscle cell plasticity in the atherosclerotic plaque. 

Side Activities

  • Editorial scientific board ATVB, Cardiovascular research, Atherosclerosis, Eur J Cardiovascular Pharmacology

    Board member of Dutch Atherosclerosis Society

    Review board LS7 EU-ERC advanced grants

     

Research Output (601)

Cardiovascular imaging of women and men visiting the outpatient clinic with chest pain or discomfort:design and rationale of the ARGUS Study

Groepenhoff Floor, Eikendal Anouk L M, Bots Sophie Heleen, van Ommen Anne-Mar, Overmars L M, Kapteijn Daniek, Pasterkamp Gerard, Reiber Johan H C, Hautemann David, Menken Roxana, Wittekoek Marianne E, Hofstra Leonard, Onland-Moret N Charlotte, Haitjema Saskia, Hoefer Imo, Leiner Tim, den Ruijter Hester M 15 dec 2020, In: BMJ Open. 10 , p. e040712

Preemptive Stenting of the Vulnerable Plaque:Fixing a Dogma?

Pasterkamp Gerard, van der Harst Pim, den Ruijter Hester M 17 nov 2020, In: Journal of the American College of Cardiology. 76 , p. 2302-2304 3 p.

The age- and sex-specific composition of atherosclerotic plaques in vascular surgery patients

de Bakker Marie, Timmerman Nathalie, van Koeverden Ian D, de Kleijn Dominique P V, de Borst Gert J, Pasterkamp Gerard, Boersma Eric, den Ruijter Hester M okt 2020, In: Atherosclerosis. 310 , p. 1-10 10 p.

The TAXINOMISIS Project:A multidisciplinary approach for the development of a new risk stratification model for patients with asymptomatic carotid artery stenosis

Timmerman Nathalie, Galyfos George, Sigala Fragiska, Thanopoulou Kalliopi, de Borst Gert J, Davidovic Lazar, Eckstein Hans-Henning, Filipovic Nenad, Grugni Roberto, Kallmayer Michael, de Kleijn Dominique P V, Koncar Igor, Mantzaris Michalis D, Marchal Elisabeth, Matsagkas Miltiadis, Mutavdzic Perica, Palombo Domenico, Pasterkamp Gerard, Potsika Vassiliki T, Andreakos Evangelos, Fotiadis Dimitrios I, 20 sep 2020, In: European Journal of Clinical Investigation. 50 , p. e13411

Intrinsic transcriptomic sex differences in human endothelial cells at birth and in adults are associated with coronary artery disease targets

Hartman Robin J G, Kapteijn Daniek M C, Haitjema Saskia, Bekker Mireille N, Mokry Michal, Pasterkamp Gerard, Civelek Mete, den Ruijter Hester M 23 jul 2020, In: Scientific Reports. 10 12 p.

Plasma extracellular vesicle proteins are associated with stress-induced myocardial ischemia in women presenting with chest pain

Dekker Mirthe, Waissi Farahnaz, van Bennekom Joelle, Silvis Max J M, Timmerman Nathalie, Bank Ingrid E M, Walter Joan E, Mueller Christian, Schoneveld A H, Schiffelers Raymond M, Pasterkamp Gerard, Grobbee Diederick E, de Winter Robbert J, Mosterd A, de Kleijn Dominique P V, Timmers Leo 23 jul 2020, In: Scientific Reports. 10 8 p.

Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis

Alencar Gabriel F, Owsiany Katherine M, K Santosh, Sukhavasi Katyayani, Mocci Giuseppe, Nguyen Anh, Williams Corey M, Shamsuzzaman Sohel, Mokry Michal, Henderson Christopher A, Haskins Ryan, Baylis Richard A, Finn Aloke V, McNamara Coleen A, Zunder Eli R, Venkata Vamsidhar, Pasterkamp Gerard, Björkegren Johan, Bekiranov Stefan, Owens Gary K 17 jul 2020, In: Circulation. 142 , p. 2045-2059 15 p.

H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

Pei Jiayi, Harakalova Magdalena, Treibel Thomas A, Lumbers R Thomas, Boukens Bastiaan J, Efimov Igor R, van Dinter Jip T, González Arantxa, López Begoña, El Azzouzi Hamid, van den Dungen Noortje, van Dijk Christian G M, Krebber Merle M, den Ruijter Hester M, Pasterkamp Gerard, Duncker Dirk J, Nieuwenhuis Edward E S, de Weger Roel, Huibers Manon M, Vink Aryan, Moore Jason H, Moon James C, Verhaar Marianne C, Kararigas Georgios, Mokry Michal, Asselbergs Folkert W, Cheng Caroline 14 jul 2020, In: Clinical Epigenetics. 12 18 p.

Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade

Wang Ying, Nanda Vivek, Direnzo Daniel, Ye Jianqin, Xiao Sophia, Kojima Yoko, Howe Kathryn L., Jarr Kai Uwe, Flores Alyssa M., Tsantilas Pavlos, Tsao Noah, Rao Abhiram, Newman Alexandra A.C., Eberhard Anne V., Priest James R., Ruusalepp Arno, Pasterkamp Gerard, Maegdefessel Lars, Miller Clint L., Lind Lars, Koplev Simon, Björkegren Johan L.M., Owens Gary K., Ingelsson Erik, Weissman Irving L., Leeper Nicholas J. 7 jul 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117 , p. 15818-15826 9 p.

All Research Output (601)