dr. B. (Bob) Oranje

Associate Professor

  • Psychiatry

dr. B. (Bob) Oranje

Research Programs


Bob Oranje is vice director of NICHE, University Medical Center Utrecht (UMC-U), Holland, as well as senior researcher and head of the psychophysiological department of the Center for Neuropsychiatric Schizophrenia Research [CNSR], Glostrup, Denmark. Since 2009 he is lector at the Faculty of Health and Medical Sciences, Dept. of Neurology, Psychiatry, and Sensory Sciences, Copenhagen University, Denmark. Furthermore, since 2012 he is UHD at the department of Psychiatry, UMC-U, Holland, where he opened a new electrophysiological and neurocognitive lab in 2017. BO has developed a psychophysiological test-battery, the Copenhagen Psychophysiological Test Battery [CPTB]. The CPTB consists of five psychophysiological paradigms specifically designed for research on psychiatric disorders and plays a central role in the projects that he has initiated. His research primarily focusses on improving/developing medical treatment for patients with schizophrenia, autism and ADHD. Secondary goals are developing animal models for schizophrenia and determining vulnerability indicators (endophenotypes) for psychosis, schizophrenia and autism in children and adolescents, in order to try and prevent these individuals from developing these disorders later in life. As such, BO has initiated several projects, including pharmacological challenge studies in healthy volunteers, treatment studies in patients with schizophrenia, studies in children and  adolescents with developmental disorders, translational studies in animals, and a project using concurrent EEG and fMRI methodology. In addition, BO collaborates in many national and international projects. Currently, his research has been sponsored by a large number of major and minor research grants, both in Denmark and in Holland. He has been promotor, co-promotor and project-leader of a large number of preclinical and clinical projects in both Holland and Denmark.

Research line

Electrophysiologically mediated improvement of treatment for psychotic as well as developmental disorders

Most recent key publications

1: B. Oranje, B. Aggernaes, H. Rasmussen, B. H. Ebdrup, and B. Y. Glenthoj. Selective attention and mismatch negativity in antipsychotic-naive, first-episode schizophrenia patients before and after 6 months of antipsychotic monotherapy. Psychol.Med.:1-11, 2017.

2: C. Vlaskamp, B. Oranje, G. F. Madsen, J. R. Mollegaard Jepsen, S. Durston, C. Cantio, B. Glenthoj, and N. Bilenberg. Auditory processing in autism spectrum disorder: Mismatch negativity deficits. Autism Res., 2017.

3: G. F. Madsen, N. Bilenberg, J. R. Jepsen, B. Y. Glenthøj, C. Cantio, and B. Oranje. Normal P50 gating in children with autism, yet attenuated P50 amplitude in the Asperger subcategory. Autism Res. Epub, 2015.

4: L. Witten, J. F. Bastlund, B. Y. Glenthoj, C. Bundgaard, B. Steiniger-Brach, A. Mork, and B. Oranje. Comparing Pharmacological Modulation of Sensory Gating in Healthy Humans and Rats: The Effects of Reboxetine and Haloperidol. Neuropsychopharmacology, 2015.

5: N. Bak and B. Oranje. Psychophysiology-Informed (Multimodal) Imaging. Curr.Top.Behav.Neurosci. 21:371-385, 2014.

Fellowship and Awards

  • 1: ZonMW Goed Gebruik Geneesmiddelen (GGG, 2013 & 2015)

    2: Lundbeck foundation grants (main applicant personal salary 2009, 2010)

    3: Lundbeck Foundation Center for Neurovascular signaling

    4: Førskningsrådet for Sundhed of Sygdom (FSS) (co-applicant for postdoctoral researcher)

    5: The Capital region of Psychiatry 2012

Research Output (102)

Effects of bumetanide on neurodevelopmental impairments in patients with tuberous sclerosis complex:An open-label pilot study

Van Andel Dorinde M., Sprengers Jan J., Oranje Bob, Scheepers Floortje E., Jansen Floor E., Bruining Hilgo 7 mei 2020, In: Molecular Autism. 11

Structural and functional MRI of altered brain development in a novel adolescent rat model of quinpirole-induced compulsive checking behavior

Straathof Milou, Blezer Erwin L.A., van Heijningen Caroline, Smeele Christel E., van der Toorn Annette, Buitelaar Jan K., de Ruiter Saskia, Naaijen Jilly, Akkermans Sophie, Mennes Maarten, Zwiers Marcel, Ilbegi Shahrzad, Hennissen Leonie, Glennon Jeffrey C., van de Vondervoort Ilse, Kapusta Katarzyna, Bielczyk Na AAtalia, Amiri Houshang, Havenith Martha, Franke Barbara, Poelmans Geert, Bralten Janita, Heskes Tom, Sokolova Elena, Groot Perry, Williams Steven, Murphy De AAclan, Lythgoe David, Bruchhage Muriel, Dud Iulia, Voinescu Bogdan, Dittmann Ralf, Banaschewski Tobias, Brandeis Daniel, Mechler Konstantin, Berg Ruth, Wolf Isabella, Häge Alexander, Landauer Michael, Hohmann Sarah, Schlier Regina Boecker, Ruff Matthias, Mandl René, Dijkhuizen Rick, Blezer Erwin, Mol Wouter, Otte Willem, Durston Sarah, Oranje Bob, Dijkhuizen Rick, 1 apr 2020, In: European Neuropsychopharmacology. 33 , p. 58-70 13 p.

Serious Games as Potential Therapies:A Validation Study of a Neurofeedback Game

Coenen Femke, Scheepers Floortje E., Palmen Saskia J. M., de Onge Maretha, V, Oranje Bob 1 mrt 2020, In: Clinical EEG and neuroscience. 51 , p. 87-93 7 p.

Include me if you can!: Reasons for low enrollment of pediatric patients in a psychopharmacological trial

Haege A., Mechler K., Niemeyer L., Buitelaar J., Durston S., Gooskens B. R., Oranje B., Banaschewski T., Dittmann R. W. mrt 2020, In: Pharmacopsychiatry. 53 , p. 96-96

Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Postema Merel C., van Rooij Daan, Anagnostou Evdokia, Arango Celso, Auzias Guillaume, Behrmann Marlene, Filho Geraldo Busatto, Calderoni Sara, Calvo Rosa, Daly Eileen, Deruelle Christine, Di Martino Adriana, Dinstein Ilan, Duran Fabio Luis S., Durston Sarah, Ecker Christine, Ehrlich Stefan, Fair Damien, Fedor Jennifer, Feng Xin, Fitzgerald Jackie, Floris Dorothea L., Freitag Christine M., Gallagher Louise, Glahn David C., Gori Ilaria, Haar Shlomi, Hoekstra Liesbeth, Jahanshad Neda, Jalbrzikowski Maria, Janssen Joost, King Joseph A., Kong Xiang Zhen, Lazaro Luisa, Lerch Jason P., Luna Beatriz, Martinho Mauricio M., McGrath Jane, Medland Sarah E., Muratori Filippo, Murphy Clodagh M., Murphy Declan G.M., O’Hearn Kirsten, Oranje Bob, Parellada Mara, Puig Olga, Retico Alessandra, Rosa Pedro, Rubia Katya, Shook Devon, 31 okt 2019, In: Nature Communications. 10

10Kin1day: A Bottom-Up Neuroimaging Initiative

van den Heuvel Martijn P. et al. 9 mei 2019, In: Frontiers in Neurology. 10 , p. 425 7 p.

Brain Imaging of the Cortex in ADHD:A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples

Hoogman Martine et al. 24 apr 2019, In: American Journal of Psychiatry. 176 , p. 531-542 12 p.

Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project

Tillmann Julian, Caceres Antonia San Jose, Chatham Chris H., Crawley Daisy, Holt Rosemary, Oakley Bethany, Banaschewski Tobias, Baron-Cohen Simon, Boelte Sven, Buitelaar Jan K., Durston Sarah, Ham Lindsay, Loth Eva, Simonoff Emily, Spooren Will, Murphy Declan G., Charman Tony, Ahmad Jumana, Ambrosino Sara, Auyeung Bonnie, Baumeister Sarah, Beckmann Christian, Bourgeron Thomas, Bours Carsten, Brammer Michael, Brandeis Daniel, Brogna Claudia, de Bruijn Yvette, Chakrabarti Bhismadev, Cornelissen Ineke, Dell'Acqua Flavio, Dumas Guillaume, Ecker Christine, Faulkner Jessica, Frouin Vincent, Garces Pilar, Goyard David, Hayward Hannah, Hipp Joerg, Johnson Mark H., Jones Emily J. H., Kundu Prantik, Lai Meng-Chuan, D'ardhuy Xavier Liogier, Lombardo Michael, Lythgoe David J., Mandl Rene, Mason Luke, Meyer-Lindenberg Andreas, Oranje Bob 11 feb 2019, In: Autism Research. 12 , p. 645-657

Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder:Results from the EU-AIMS Longitudinal European Autism Project

Oldehinkel Marianne, Mennes Maarten, Marquand Andre, Charman Tony, Tillmann Julian, Ecker Christine, Dell'Acqua Flavio, Brandeis Daniel, Banaschewski Tobias, Baumeister Sarah, Moessnang Carolin, Baron-Cohen Simon, Holt Rosemary, Bölte Sven, Durston Sarah, Kundu Prantik, Lombardo Michael V., Spooren Will, Loth Eva, Murphy Declan G.M., Beckmann Christian F., Buitelaar Jan K., Ahmad Jumana, Ambrosino Sara, Auyeung Bonnie, Bourgeron Thomas, Bours Carsten, Brammer Michael, Brogna Claudia, de Bruijn Yvette, Chakrabarti Bhismadev, Cornelissen Ineke, Crawley Daisy, Dumas Guillaume, Faulkner Jessica, Frouin Vincent, Garcés Pilar, Goyard David, Ham Lindsay, Hayward Hannah, Hipp Joerg, Johnson Mark H., Jones Emily J.H., Lai Meng Chuan, Liogier D'ardhuy Xavier, Lythgoe David J., Mandl René, Mason Luke, Meyer-Lindenberg Andreas, Oranje Bob, 1 jan 2019, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4 , p. 260-270 11 p.

Efficacy of different types of cognitive enhancers for patients with schizophrenia:a meta-analysis

Sinkeviciute Igne, Begemann Marieke, Prikken Merel, Oranje Bob, Johnsen Erik, Lei Wan U., Hugdahl Kenneth, Kroken Rune A., Rau Carina, Jacobs Jolien D., Mattaroccia Silvia, Sommer Iris E. 1 dec 2018, In: npj Schizophrenia. 4

All Research Output (102)