dr. M. (Michal) Mokry
dr. M. (Michal) Mokry
- CDL Research
- Departement of Experimental Cardiology
Research Programs
Biography
Biography
In my research, I unravel the biological mechanisms behind atherosclerosis. I employ a combination of bulk and single-cell transcriptomics, epigenetics, and bioinformatics, and integrate these approaches with clinical datasets and in vitro experiments.
My work leverages the largest biobank of well-characterized atherosclerotic plaques from over 4,000 patients, known as the Athero-Express study. We generate a variety of complex “-omics” datasets, which include genotyping, transcriptomics (bulk, single-cell, and spatially resolved), DNA methylation (both bulk and single-cell), and proteomics. These datasets are integrated with histological and clinical data to decode the mechanisms of plaque pathogenesis. This integration enables us to pinpoint specific processes that lead to severe manifestations of atherosclerotic disease, such as stroke and myocardial infarction. Alongside computational tools, we utilize primary in vitro model systems derived from vascular and plaque cells, as well as molecular biology techniques, for validation and mechanistic studies."
Research Output (129)
Cutilli Alessandro, Jansen Suze A, Paolucci Francesca, Mokry Michal, Mocholi Enric, Lindemans Caroline A, Coffer Paul J 7 Feb 2024,
Fang Juntao, Yang Qiangbing, Maas Renée G C, Buono Michele, Meijlink Bram, Lotgerink Bruinenberg Dyonne, Benavente Ernest Diez, Mokry Michal, van Mil Alain, Qian Li, Goumans Marie-José, Schiffelers Raymond, Lei Zhiyong, Sluijter Joost P G 17 Jan 2024, In: Stem Cell Research & Therapy [E]. 15 , p. 19
Mekke Joost M, Sakkers Tim R, Verwer Maarten C, van den Dungen Noortje A M, Song Yipei, Miller Clint L, Finn Aloke V, Pasterkamp Gerard, Mokry Michal, den Ruijter Hester M, Vink Aryan, de Kleijn Dominique P V, de Borst Gert J, Haitjema Saskia, van der Laan Sander W Dec 2023, In: Scientific Reports. 13 15 p.
Chappin K, Besteman S B, Hennus M P, Wildenbeest J G, Mokry M, Bont L J, van der Vlist M, Calis J J A, 6 Nov 2023, In: The Journal of infectious diseases. 229 , p. S100-S111 12 p.
Buono Michele F, Benavente Ernest Diez, Slenders Lotte, Methorst Daisey, Tessels Daniëlle, Mili Eloi, Finger Roxy, Kapteijn Daniek, Daniels Mark, van den Dungen Noortje A M, Calis Jorg J A, Mol Barend M, de Borst Gert J, de Kleijn Dominique P V, Pasterkamp Gerard, den Ruijter Hester M, Mokry Michal 27 Oct 2023, In: Journal of the American Heart Association. 12
Kawai Kenji, Sakamoto Atsushi, Mokry Michal, Ghosh Saikat Kumar B, Kawakami Rika, Xu Weili, Guo Liang, Fuller Daniela, Tanaka Takamasa, Shah Palak, Cornelissen Anne, Sato Yu, Mori Masayuki, Konishi Takao, Vozenilek Aimee E, Dhingra Roma, Virmani Renu, Pasterkamp Gerard, Finn Aloke V 26 Oct 2023, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 43 , p. 2333-2347 15 p.
Sakkers Tim R, Mokry Michal, Civelek Mete, Erdmann Jeanette, Pasterkamp Gerard, Diez Benavente Ernest, den Ruijter Hester M 5 Oct 2023, In: Atherosclerosis. 384
Li Weizhen, Lin Alexander, Hutton Michael, Dhaliwal Harkirat, Nadel James, Rodor Julie, Tumanov Sergey, Örd Tiit, Hadden Matthew, Mokry Michal, Mol Barend M, Pasterkamp Gerard, Padula Matthew P, Geczy Carolyn L, Ramaswamy Yogambha, Sluimer Judith C, Kaikkonen Minna U, Stocker Roland, Baker Andrew H, Fisher Edward A, Patel Sanjay, Misra Ashish 3 Oct 2023, 22 p.
Kavousi Maryam et al. 28 Sep 2023, In: Nature Genetics. 55 , p. 1651-1664 14 p.
Benavente Ernest Diez, Karnewar Santosh, Buono Michele, Mili Eloi, Hartman Robin J G, Kapteijn Daniek, Slenders Lotte, Daniels Mark, Aherrahrou Redouane, Reinberger Tobias, Mol Barend M, de Borst Gert J, de Kleijn Dominique P V, Prange Koen H M, Depuydt Marie A C, de Winther Menno P J, Kuiper Johan, Björkegren Johan L M, Erdmann Jeanette, Civelek Mete, Mokry Michal, Owens Gary K, Pasterkamp Gerard, den Ruijter Hester M 17 Aug 2023, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 43 , p. 1836-1850 15 p.