dr. dr.h.c.mult A.L.G. (Alexander) Leemans

Associate Professor

  • Image Sciences Institute

dr. dr.h.c.mult A.L.G. (Alexander) Leemans

Research Programs


Alexander Leemans is a physicist who received his Ph.D. in 2006 at the University of Antwerp, Belgium. From 2007 to 2009, he worked as a postdoctoral researcher at the Cardiff University Brain Research Imaging Center (CUBRIC), Cardiff University, Wales, United Kingdom. In 2009, he joined the Image Sciences Institute (ISI), University Medical Center Utrecht, the Netherlands, where he currently holds a tenured faculty position as Associate Professor. His current research interests include modeling, processing, visualizing and analyzing diffusion MRI data for investigating microstructural and architectural tissue organization. He heads the PROVIDI Lab and is the developer of ExploreDTI, which is a graphical toolbox for investigating diffusion MRI data.

Research line

Diffusion MRI

Most recent key publications

1: C. Lebel, L. Walker, A. Leemans, L. Phillips, C. Beaulieu, "Microstructural Maturation of the Human Brain from Childhood to Adulthood", NeuroImage, 2008, nr. 3, vol. 40, pp. 1044-1055
2: A. Leemans, D.K. Jones, "The B-matrix must be rotated when correcting for subject motion in DTI data", Magnetic Resonance in Medicine, 2009, nr. 1, vol. 62, pp. 1336-1349
3: J.D. Tournier, S. Mori, A. Leemans, "Diffusion tensor imaging and beyond", Magnetic Resonance in Medicine, 2011, nr. 6, vol. 65, pp. 1532-1556
4: B. Jeurissen, A. Leemans, J.D. Tournier, D.K. Jones, J. Sijbers, "Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion MRI", Human Brain Mapping, 2013, nr. 11, vol. 34, pp. 2747-2766
5: S.B. Vos, D.K. Jones, M.A. Viergever, A. Leemans, "Partial volume effect as a hidden covariate in DTI analyses", NeuroImage, 2011, nr. 4, vol. 55, pp. 1566-1576

Fellowship and Awards

  • VIDI (NWO)

    FC-EW (NWO)


    PhD fellowship (IWT)

    Honorary Doctorate (Chubut)

    Young Investigator Award (BHPA)

    Outstanding Teacher Award (ISMRM)

Research Output (234)

Dose-dependent volume loss in subcortical deep grey matter structures after cranial radiotherapy

Nagtegaal Steven H J, David Szabolcs, Philippens Marielle E P, Snijders Tom J, Leemans Alexander, Verhoeff Joost J C jan 2021, In: Clinical and translational radiation oncology. 26 , p. 35-41 7 p.

The YOUth cohort study:MRI protocol and test-retest reliability in adults

Buimer Elizabeth E.L., Pas Pascal, Brouwer Rachel M., Froeling Martijn, Hoogduin Hans, Leemans Alexander, Luijten Peter, van Nierop Bastiaan J., Raemaekers Mathijs, Schnack Hugo G., Teeuw Jalmar, Vink Matthijs, Visser Fredy, Hulshoff Pol Hilleke E., Mandl René C.W. okt 2020, In: Developmental Cognitive Neuroscience. 45

Structural Network Analysis Using Diffusion MRI Tractography in Parkinson's Disease and Correlations With Motor Impairment

Kok Jelmer G., Leemans Alexander, Teune Laura K., Leenders Klaus L., McKeown Martin J., Appel-Cresswell Silke, Kremer Hubertus P.H., de Jong Bauke M. 2 sep 2020, In: Frontiers in Neurology. 11

Effect of radiation therapy on cerebral cortical thickness in glioma patients:Treatment-induced thinning of the healthy cortex

Nagtegaal Steven H J, David Szabolcs, Snijders Tom J, Philippens Marielle E P, Leemans Alexander, Verhoeff Joost J C 10 jul 2020, In: Neuro-oncology advances. 2 8 p.

Automated characterization of noise distributions in diffusion MRI data

St-Jean SJGRY, de Luca A, Tax Chantal, Viergever Max A., Leemans Alexander 17 jun 2020, In: Medical Image Analysis. 65 18 p.

Reduced hippocampal volume in adolescents with psychotic experiences:A longitudinal population-based study

Calvo Ana, Roddy Darren W., Coughlan Helen, Kelleher Ian, Healy Colm, Harley Michelle, Clarke Mary, Leemans Alexander, Frodl Thomas, O'Hanlon Erik, Cannon Mary 1 jun 2020, In: PLoS ONE. 15

Generalized Richardson-Lucy (GRL) for analyzing multi-shell diffusion MRI data

Guo Fenghua, Leemans Alexander, Viergever Max A, Dell'Acqua Flavio, De Luca Alberto 16 mei 2020, In: NeuroImage. 218 16 p.

Effect of Fixed-Density Thresholding on Structural Brain Networks:A Demonstration in Cerebral Small Vessel Disease

de Brito Robalo Bruno M, Vlegels Naomi, Meier Jil, Leemans Alexander, Biessels Geert Jan, Reijmer Yael D, apr 2020, In: Brain Connectivity. 10 , p. 121-133 13 p.

Perinatal thalamic injury: MRI predictors of electrical status epilepticus in sleep and long-term neurodevelopment

van den Munckhof Bart, Zwart Anne F, Weeke Lauren C, Claessens Nathalie H P, Plate Joost D J, Leemans Alexander, Kuijf Hugo J, van Teeseling Heleen C, Leijten Frans S S, Benders Manon J N, Braun Kees P J, de Vries Linda S, Jansen Floor E 25 feb 2020, In: NeuroImage. Clinical. 26 9 p.

Indirect frontocingulate structural connectivity predicts clinical response to accelerated rTMS in major depressive disorder

Klooster Deborah C.W., Vos Iris N., Caeyenberghs Karen, Leemans Alexander, David Szabolcs, Besseling René M.H., Aldenkamp Albert P., Baeken Chris 28 jan 2020, In: Journal of Psychiatry and Neuroscience. 45 , p. 243-252 10 p.

All Research Output (234)