dr. E.F. Knol

Associate Professor

  • Laboratory for Translational Immunology (LTI)
  • Laboratory for Translational Immunology (LTI)
  • Dermatology and Allergology
  • Dermatology and Allergology

dr. E.F. Knol

Research Programs


Edward Knol is a biomedical scientist and immunologist in the departments of Immunology and Dermatology/Allergology at the University Medical Center Utrecht. He did his PhD training in the Blood Transfusion Service of the University of Amsterdam and had a postdoc position at Johns Hopkins University in Baltimore. His scientific research focuses on allergic diseases, in particularly eczema and food allergy. The research focusses on 1) improved insights in pathomechanisms, 2) explore new treatment options, 3) improve current diagnostics and establish new diagnostics platforms. In his career Edward Knol discovered CD63 as the basophil activation marker, described the important role of the peanut allergen Ara h 2 and described A20/TNFAIP3 dysregulation in atopic dermatitis. He is involved in several (inter)national collaborations and is Secretary General of the Dutch Society of Immunology (~1400 members).

Within the University Medical Center he holds a teaching position and chairs the education committee of the University Utrecht graduate school Immunity and Infection (50 master and 170 PhD students). He is coordinator and examiner of: 1) Course Clinical Immunology for 3rd years students Biomedical Sciences, 2) Course Immune Therapy for 2nd years student Medicine and 3) Course Infection and Immunity for 3rd years Students at the Technical University Eindhoven. 

At the international level Edward Knol has organised 3 European Academy of Allergy and Clinical Immunology (EAACI) Winter schools and was the chair of the Scientific Program Committee of the EAACI annual meetings in 2014-2016. In addition, since 2019 he is Vice President Congresses of EAACI. 

Specialties: Immunology, Allergy, Food Allergy, Atopic Dermatitis, Basophilic granulocytes, T lymphocytes, allergy diagnostic tests, basophil activation test



Google Scholar:

Scopus H-factor: h-index: 51

Research gate: h-index: 54, : RG score: 46,95

Google Scholar: h-index: 60 


Side Activities

  • 2009- Chair Educational committee Master and PhD program Graduate School Immunity and Infection, University van Utrecht. Supervising the training program of 50 Master students and 180 PhD students.

    2013- Co-director FOCIS Center of Excellence, Utrecht Infection and Immunity Center.

    2014- Member taskforce IgE diagnostics, EAACI

    2015- Member guideline committee Allergy Immunotherapy, EAACI

    2015-2018 Steering committee member FOCIS, representing EAACI

    2014-2016 Chair Scientific Program Committee (SPC) EAACI, coordinating EAACI annual meetings in 2015 (Barcelona) and 2016 (Vienna).

    2019- Vice President EAACI Congresses and Events, coordinating all scientific meetings of European Academy of Allergy and Clinical Immunology ranging from 8500 participants to 280 participants per meeting


    Editorial Board memberships:

    - Dutch Journal for Allergology

    - Clinical and Translational Allergy

    - Clinical and Experimental Allergy




Research Output (245)

EASI p-EASI: Predicting disease severity in atopic dermatitis patients treated with dupilumab using a combination of serum biomarkers

Bakker Daphne S, Ariens Lieneke F M, Giovannone Barbara, Hijnen DirkJan, Delemarre Eveline M, Knol Edward, Nierkens Stefan, de Bruin-Weller Marjolein S, Thijs Judith L, Drylewicz Julia dec 2020, In: Allergy. 75 , p. 3287-3289 3 p.

Handling of allergen immunotherapy in the COVID-19 pandemic:An ARIA-EAACI statement

Klimek Ludger, Jutel Marek, Akdis Cezmi, Bousquet Jean, Akdis Mübeccel, Bachert Claus, Agache Ioana, Ansotegui Ignacio, Bedbrook Anna, Bosnic-Anticevich Sinthia, Canonica Giorgio W, Chivato Tomas, Cruz Alvaro A, Czarlewski Wiencyslawa, Giacco Stefano Del, Du Hui, Fonseca Joao A, Gao Yadong, Haahtela Tari, Hoffmann-Sommergruber Karin, Ivancevich Juan-Carlos, Khaltaev Nikolai, Knol Edward F, Kuna Piotr, Larenas-Linnemann Desiree, Melen Erik, Mullol Joaquim, Naclerio Robert, Ohta Ken, Okamoto Yoshitaka, O'Mahony Liam, Onorato Gabrielle L, Papadopoulos Nikos G, Pawankar Ruby, Pfaar Oliver, Samolinski Boleslaw, Schwarze Jurgen, Toppila-Salmi Sanna, Shamji Mohamed H, Ventura Maria Teresa, Valiulis Arunas, Yorgancioglu Arzu, Matricardi Paolo, Zuberbier Torsten, 24 apr 2020, In: Allergy. 75 , p. 1546-1554 9 p.

Response of FcεRI-bearing leucocytes to omalizumab in chronic spontaneous urticaria

Alizadeh Aghdam M, Knol E F, van den Elzen M, den Hartog Jager C, van Os-Medendorp H, Knulst A C, Otten H G, Röckmann H 10 jan 2020, In: Clinical and Experimental Allergy. 50 , p. 364-371 8 p.

Dupilumab is very effective in a large cohort of difficult-to-treat adult atopic dermatitis patients: First clinical and biomarker results from the BioDay registry

Ariens Lieneke F. M., van der Schaft Jorien, Bakker Daphne S., Balak Deepak, Romeijn Margreet L. E., Kouwenhoven Tessa, Kamsteeg Marijke, Giovannone Barbara, Drylewicz Julia, van Amerongen Cynthia Catalina Aurora, Delemarre Evelien M., Knol Edward F., van Wijk Femke, Nierkens Stefan, Thijs Judith L., Schuttelaar Marie L. A., de Bruin-Weller Marjolein S. 1 jan 2020, In: Allergy. 75 , p. 116-126 11 p.

Early identification of atopic dermatitis patients in need of systemic immunosuppressive treatment

Bakker Daphne S., Drylewicz Julia, Nierkens Stefan, Knol Edward F., Giovannone Barbara, Delemarre Eveline M., van der Schaft Jorien, Balak Deepak M.W., de Bruin-Weller Marjolein S., Thijs Judith L. dec 2019, In: Clinical and Experimental Allergy. 49 , p. 1641-1644 4 p.

Management of Cow's Milk Allergy from an Immunological Perspective:What Are the Options?

Knol Edward F, Jong Nicolette W de, Ulfman Laurien H, Tiemessen Machteld M 11 nov 2019, In: Nutrients. 11 8 p.

Biomarkers detected in dried blood spots from atopic dermatitis patients strongly correlate with disease severity

Thijs Judith L., Fiechter Renée, Giovannone Barbara, de Bruin-Weller Marjolein S., Knol Edward F., Bruijnzeel-Koomen Carla A.F.M., Drylewicz Julia, Nierkens Stefan, Hijnen Dirk Jan nov 2019, In: Allergy: European Journal of Allergy and Clinical Immunology. 74 , p. 2240-2243 4 p.

Predicting treatment response to methotrexate in atopic dermatitis patients using clinical characteristics and serum biomarkers

Ariens L., Thijs J., Bakker D., Drylewicz J., Nierkens Stefan, Knol E., Delemarre E., Balak D., van der Schaft J., de Bruin-Weller M. sep 2019, In: Journal of Investigative Dermatology. 139 , p. S287-S287

All Research Output (245)