prof. dr. H.E. (Hilleke) Hulshoffpol

Full Professor

  • Psychiatry

prof. dr. H.E. (Hilleke) Hulshoffpol

Research Programs


Hilleke Hulshoff Pol completed her MS degree in psychophysiology with Rien Verbaten in Utrecht (1987), her internship in neuropsychology and neuroimaging with Nelson Butters at the University of California in San Diego (1988), and subsequently her PhD degree in Utrecht (September 25, 1995) with Jan van Ree (neuropharmacology), Max Viergever (imaging), and Cees Tulleken (neurosurgery). Topic of her thesis was memory processes in the frontal cortex of the human brain. Between 1996 and 2006 she set up and headed the brain imaging research lab at the Department of Psychiatry in Utrecht. Since 2007 she is full professor of neuroscience in particular of psychiatric disorders at the Brain Center Rudolf Magnus.

Her research focuses on structural and functional brain plasticity throughout life in health and in psychiatric disease, and the influences of genes and environment on brain plasticity. For this purpose she studies individuals and their (twin) family members, using magnetic resonance imaging at (ultra) high field. She has received a VIDI award from the Netherlands Scientific Organization NWO, and a High Potential award from the Utrecht University. Her work was published in >220 publications, her current h-index is 64, and has been cited >15.800 times.

Research line

Brain plasticity

Most recent key publications

1:Teeuw J., Brouwer R.M., Guimarães, J.P.O.F.T., Brandner, P., Koenis M., Swagerman S., Verwoert, M., Boomsma D.I., Hulshoff Pol H.E. (2019) Genetic and environmental influences on functional connectivity within and between canonical cortical resting-state networks throughout adolescent development in boys and girls. Neuroimage. doi: 10.1016/j.neuroimage.2019.116073

2:Brouwer RM Panizzon MS Glahn DC, Hibar DP, Hua X, Jahanshad N, Abramovic L, de Zubicaray GI Franz CE, Hansell NK, Hickie IB, Koenis MMG, Martin NG, Mather KA, McMahon KL, Schnack HG, Strike LT, Swagerman SC, Thalamuthu A, Wen W, Gilmore JH, Gogtay N, Kahn RS, Sachdev PS, Wright MJ, Boomsma DI, Kremen WS, Thompson PM, Hulshoff Pol HE. (2017). Genetic influences on longitudinal changes in global and subcortical brain volumes: results of the ENIGMA Plasticity Working Group. Hum Brain Mapp. 38(9):4444-4458

3:Bohlken MM, Brouwer RM, Mandl RC, Van den Heuvel MP, Hedman AM, De Hert M, Cahn W, Kahn RS, Hulshoff Pol HE. (2016). Structural Brain Connectivity as a Genetic Marker for Schizophrenia. JAMA Psychiatry. 73(1):11-9.

4:Svatkova A, Mandl RC, Scheewe TW, Cahn W, Kahn RS, Hulshoff Pol HE. (2015). Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls. Schizophr Bull.41(4):869-78.

5:Schnack HG, van Haren NE, Brouwer RM, Evans A, Durston S, Boomsma DI, Kahn RS, Hulshoff Pol HE. (2015). Changes in thickness and surface area of the human cortex and their relationship with intelligence. Cereb Cortex. 25(6):1608-17.

6:Marsman A, Mandl RC, Klomp DW, Bohlken MM, Boer VO, Andreychenko A, Cahn W, Kahn RS, Luijten PR, Hulshoff Pol HE. (2014). GABA and glutamate in schizophrenia: a 7 T ¹H-MRS study. Neuroimage Clin. 15;6:398-407.

Side Activities

  • None

Fellowship and Awards

  • Alzheimer's Association Zenith Award Program (subaward PI) 2020

    NWA Ideas Generator (one of the PIs) 2020

    NIH ENIGMA World Aging Center (subward PI) 2018

    NWA NeuroLabNL (subward PI) 2018

    Dutch Brain Foundation (subaward PI) 2018

    NWO National Roadmap BBMRI-NL2.0 (one of the PIs) 2014

    NWO Gravitation Grant CID (one of the PIs), 2012

    NWO  NIHC Brain and Cognition, programmes of excellence (PI), 2010

    High Potential Program Utrecht University (one of the two PIs), 2007

    Marie Curie research training network (PI for Utrecht), 2007

    NWO ZON-MW VIDI program (PI), 2004

Research Output (277)

The YOUth cohort study:MRI protocol and test-retest reliability in adults

Buimer Elizabeth E.L., Pas Pascal, Brouwer Rachel M., Froeling Martijn, Hoogduin Hans, Leemans Alexander, Luijten Peter, van Nierop Bastiaan J., Raemaekers Mathijs, Schnack Hugo G., Teeuw Jalmar, Vink Matthijs, Visser Fredy, Hulshoff Pol Hilleke E., Mandl René C.W. okt 2020, In: Developmental Cognitive Neuroscience. 45

Exploring the Temporal Relation between Body Mass Index and Corticosteroid Metabolite Excretion in Childhood

Van Keulen Britt J, Dolan Conor V, Andrew Ruth, Walker Brian R, Hulshoff Pol Hilleke E, Boomsma Dorret I, Rotteveel Joost, Finken Martijn J J 23 mei 2020, In: Nutrients. 12

ENIGMA and global neuroscience:A decade of large-scale studies of the brain in health and disease across more than 40 countries

Thompson Paul M., Jahanshad Neda, Ching Christopher R.K., Salminen Lauren E., Thomopoulos Sophia I., Bright Joanna, Baune Bernhard T., Bertolín Sara, Bralten Janita, Bruin Willem B., Bülow Robin, Chen Jian, Chye Yann, Dannlowski Udo, de Kovel Carolien G.F., Donohoe Gary, Eyler Lisa T., Faraone Stephen V., Favre Pauline, Filippi Courtney A., Frodl Thomas, Garijo Daniel, Gil Yolanda, Grabe Hans J., Grasby Katrina L., Hajek Tomas, Han Laura K.M., Hatton Sean N., Hilbert Kevin, Ho Tiffany C., Holleran Laurena, Homuth Georg, Hosten Norbert, Houenou Josselin, Ivanov Iliyan, Jia Tianye, Kelly Sinead, Klein Marieke, Kwon Jun Soo, Laansma Max A., Leerssen Jeanne, Lueken Ulrike, Nunes Abraham, Neill Joseph O’, Opel Nils, Piras Fabrizio, Brouwer Rachel M., de Zwarte Sonja M.C., Hulshoff Pol Hilleke E., van Haren Neeltje E.M., 20 mrt 2020, In: Translational Psychiatry. 10

The genetic architecture of the human cerebral cortex

Grasby Katrina L, Jahanshad Neda, Painter Jodie N, Colodro-Conde Lucía, Bralten Janita, Hibar Derrek P, Lind Penelope A, Pizzagalli Fabrizio, Ching Christopher R K, McMahon Mary Agnes B, Shatokhina Natalia, Zsembik Leo C P, Thomopoulos Sophia I, Zhu Alyssa H, Strike Lachlan T, Agartz Ingrid, Alhusaini Saud, Almeida Marcio A A, Alnæs Dag, Amlien Inge K, Andersson Micael, Ard Tyler, Armstrong Nicola J, Ashley-Koch Allison, Atkins Joshua R, Bernard Manon, Brouwer Rachel M, Buimer Elizabeth E L, Bülow Robin, Bürger Christian, Cannon Dara M, Chakravarty Mallar, Chen Qiang, Cheung Joshua W, Couvy-Duchesne Baptiste, Dale Anders M, Dalvie Shareefa, de Araujo Tânia K, de Zubicaray Greig I, de Zwarte Sonja M C, Klein Marieke, van Haren Neeltje E M, Veldink Jan H, Ayesa-Arriola Rosa, Cahn Wiepke, Hillegers Manon H J, Hulshoff Pol Hilleke E, Kahn René S, Ophoff Roel A, Sommer Iris E, 20 mrt 2020, In: Science. 367 , p. 1340-+

Heritability of Cortisol Production and Metabolism Throughout Adolescence

van Keulen Britt J., Dolan Conor V., Andrew Ruth, Walker Brian R., Hulshoff Pol Hilleke E., Boomsma Dorret I., Rotteveel Joost, Finken Martijn J.J. 1 feb 2020, In: The Journal of clinical endocrinology and metabolism. 105

Long-Term Stability of Cortisol Production and Metabolism throughout Adolescence:Longitudinal Twin Study

Van Keulen Britt J., Dolan Conor V., Andrew Ruth, Walker Brian R., Hulshoff Pol Hilleke E., Boomsma Dorret I., Rotteveel Joost, Finken Martijn J.J. feb 2020, In: Twin Research and Human Genetics. 23 , p. 33-38 6 p.

Structural methods in gray matter

Mandl René C.W., Schnack Hugo G., Brouwer Rachel M., Hulshoff Pol Hilleke E. 1 jan 2020, p. 3-26 24 p.

Genetic architecture of subcortical brain structures in 38,851 individuals

Satizabal Claudia L., Adams Hieab H.H., Hibar Derrek P., White Charles C., Knol Maria J., Stein Jason L., Scholz Markus, Sargurupremraj Muralidharan, Jahanshad Neda, Roshchupkin Gennady V., Smith Albert V., Bis Joshua C., Jian Xueqiu, Luciano Michelle, Hofer Edith, Teumer Alexander, van der Lee Sven J., Yang Jingyun, Yanek Lisa R., Lee Tom V., Li Shuo, Hu Yanhui, Koh Jia Yu, Eicher John D., Desrivières Sylvane, Arias-Vasquez Alejandro, Chauhan Ganesh, Athanasiu Lavinia, Rentería Miguel E., Kim Sungeun, Hoehn David, Armstrong Nicola J., Chen Qiang, Holmes Avram J., den Braber Anouk, Kloszewska Iwona, Andersson Micael, Abramovic Lucija, Bohlken Marc M., Klein Marieke, Boks Marco P., van Eijk Kristel R., Cahn Wiepke, Hulshoff Pol Hilleke E., Ikram M. Kamran, Brouwer Rachel M., Kahn René S., Ophoff Roel A., van Haren Neeltje E.M., Schmidt Reinhold, 1 nov 2019, In: Nature Genetics. 51 , p. 1624-1636 13 p.

Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition

van der Meer Dennis, Sønderby Ida E, Kaufmann Tobias, Walters G Bragi, Abdellaoui Abdel, Ames David, Amunts Katrin, Andersson Micael, Armstrong Nicola J, Bernard Manon, Blackburn Nicholas B, Blangero John, Boomsma Dorret I, Brodaty Henry, Brouwer Rachel M, Bülow Robin, Cahn Wiepke, Calhoun Vince D, Caspers Svenja, Cavalleri Gianpiero L, Ching Christopher R K, Cichon Sven, Ciufolini Simone, Corvin Aiden, Crespo-Facorro Benedicto, Curran Joanne E, Dalvie Shareefa, Dazzan Paola, de Geus Eco J C, de Zubicaray Greig I, de Zwarte Sonja M C, Delanty Norman, den Braber Anouk, Desrivieres Sylvane, Di Forti Marta, Doherty Joanne L, Donohoe Gary, Ehrlich Stefan, Eising Else, Espeseth Thomas, Fisher Simon E, Fladby Tormod, Frei Oleksandr, Frouin Vincent, Fukunaga Masaki, Gareau Thomas, Glahn David C, Hillegers Manon H J, Hulshoff Pol Hilleke E, Ophoff Roel A, 30 okt 2019, In: JAMA Psychiatry. 77 , p. 420-430 11 p.

Sexual dimorphism in cortisol production and metabolism throughout pubertal development: a longitudinal study

van Keulen Britt, Dolan Conor, van der Voorn Bibian, Andrew Ruth, Walker Brian, Boomsma Dorret, Hulshoff-Pol Hilleke, Rotteveel Joost, Finken Martijn sep 2019, In: Hormone Research in Paediatrics. 91 , p. 59-60

All Research Output (277)