dr. ir. D. (Debby) GawlittaAssociate Professor
- Department of Oral and Maxillofacial Surgery, Prosthodontics and Special Dental Care
Dr. Debby Gawlitta is an associate Professor working on maxillofacial tissue regeneration, particularly focusing on bone regeneration. She is inspired by the natural mechanisms of the body for bone development and repair that she aims to adopt in her regenerative strategies. Translation of the regenerative strategies to clinical practice is driving current research.
Consequently, she aims to mimic the process of endochondral bone regeneration (via a cartilage intermediate - such as seen in the growth plate) to ultimately restore defects in patients. Recently, she showed the potential of allogeneic cells in this regenerative approach and currently studies the importance of the interaction of the immune system with this process. The use of allogeneic cells would ease therapeutic interventions in pateints. Furthermore, her group is focusing on vascularization strategies for bone regeneration to be able to create engineered bone tissue that is large enough to treat patient defects.
Research keywords include bone regeneration, clinical translation, biomaterials, stem/progenitor cells (MSCs), osteoimmunology, bioreactors, and 3D bioprinting.
Dr. Gawlitta was trained as a biomedical engineer at the Eindhoven University of Technology. Her PhD thesis was focused on generating engineered skeletal muscle tissue to model and monitor the development of pressure ulcers.
In 2007, she moved to the department of Orthopaedics, University Medical Center in Utrecht, to work on bone and cartilage tissue regeneration within the Hospital's strategic impulse on regenerative medicine. During this postdoctoral period, she received a prestigious Veni grant (Dutch innovation grant) to pursue (endochondral) bone regeneration from a cartilage template with bone marrow-derived stem cells.
In 2014, she moved to the department of 'Oral and Maxillofacial Surgery & Special Dental Care' to establish her own group focusing on craniomaxillofacial bone regeneration. She currently holds a position as Associate Professor, supervising her group in the RMCU (Regenerative Medicine Center Utrecht). In 2016 she received a start-up grant from the AO Foundation to continue her endochondral research line. She has published over 50 peer-reviewed papers.
Further, Debby Gawlitta developed and coordinates the 2-year Master’s program RMT – Regenerative Medicine and Technology. Since 2012, RMT is a collaborative program of the UMCU, Utrecht University and Eindhoven University of Technology.
Board member of the Strategic Research Program (speerpunt) 'Regenerative Medicine and Stem Cells', UMC Utrecht
Member of the internationalization committee of the UMC Utrecht
Member of the local organizing committee of the ESB 2018 (annual meeting of the European Society for Biomaterials).
Scientific board member of the Regenerative Medicine Center Utrecht
Coordinator of Master's program 'Regenerative Medicine and Technology'
Teaching of various annual Bachelor, Master’s, PhD and Summer school lectures in the Biomedical Sciences, Veterinary Sciences, and Medicine curricula on e.g. Biomechanics, Bone Tissue Engineering and Bioreactors.
Reviewer for several journals, including Tissue Engineering, Biofabrication, Biomaterials, Biomedical Materials Research
Fellowship and Awards
2018: H2020-MSCA-COFUND 'RESCUE' (co-applicant)
2017: AO grant (AOCMF-17-17G) ‘MACRON: Mandibular Condyle Regeneration’ (€ 350,000)
2016: AO Foundation start-up grant (S-16-130G) ‘Clinical translation of endochondral bone regeneration’ (€ 107,000)
2016: Selected for the Research Talent Program of the UMC Utrecht
2014: Internal grant of UMC Utrecht for translational research (€ 33,300)
2013: NWO (Dutch Science Foundation) Graduate Program grant (€ 800,000)
2012: Selected for the Steyn Parvé program for stimulation of excellent female scientists of UMC Utrecht
2010: Veni: personal innovational incentive grant entitled ‘Mimicking nature: growing bone from cartilage’ was awarded by STW (Dutch technology foundation) (€250,000)
2008: Award for best thesis at the faculty of Biomedical Engineering at the Eindhoven University of Technology
2000: Award for internship at foreign institute (Eindhoven University of Technology)
Research Output (43)
van Velthoven Melissa J J, Ramadan Rana, Zügel Franziska S, Klotz Barbara J, Gawlitta Debby, Costa Pedro F, Malda Jos, Castilho Miguel, de Kort Laetitia M O, de Graaf Petra 23 feb 2020, In: Tissue engineering. Part C, Methods. 26 , p. 190-198 9 p.
Longoni A, Utomo L, van Hooijdonk I E, Bittermann G K, Vetter V C, Kruijt Spanjer E C, Ross J, Rosenberg A J, Gawlitta D 21 feb 2020, In: European Cells & Materials. 39 , p. 121-135 15 p.
Boot W, Vogely H C, Nikkels P G, Pouran B, van Rijen M H, Ekkelenkamp M B, Hänsch G M, Dhert W J, Gawlitta D 19 feb 2020, In: European Cells & Materials. 39 , p. 108-120 13 p.
Pennings Iris, van Haaften Eline E, Jungst Tomasz, Bulsink Jurgen A, Rosenberg Antoine, Groll Jürgen, Bouten Carlijn V C, Kurniawan Nicholas A, Smits Anthal I P M, Gawlitta Debby 18 nov 2019, In: Biofabrication. 12 13 p.
Jungst Tomasz, Pennings Iris, Schmitz Michael, Rosenberg Antoine J.W.P., Groll Jürgen, Gawlitta Debby 1 okt 2019, In: Advanced Functional Materials. 29
Garcia João P, Longoni Alessia, Gawlitta Debby, J W P Rosenberg Antoine, Grinstaff Mark W, Töyräs Juha, Weinans Harrie, Creemers Laura B, Pouran Behdad 30 sep 2019, In: Acta Biomaterialia. 100 , p. 202-212 11 p.
Koolen M, Longoni A, van der Stok J, Van der Jagt O, Gawlitta D, Weinans H 17 sep 2019, In: European Cells & Materials. 38 , p. 94-105 12 p.
Klotz Barbara J, Oosterhoff Loes A, Utomo Lizette, Lim Khoon S, Vallmajo-Martin Queralt, Clevers Hans, Woodfield Tim B F, Rosenberg Antoine J W P, Malda Jos, Ehrbar Martin, Spee Bart, Gawlitta Debby 12 aug 2019, In: Advanced Healthcare Materials. 8
Lim Khoon S, Klotz BJ, Lindberg Gabriella C J, Melchels Ferry P W, Hooper Gary J, Malda Jos, Gawlitta Debby, Woodfield Tim B F 26 apr 2019, In: Macromolecular Bioscience. 19 14 p.
Pennings I, van Dijk L A, van Huuksloot J, Fledderus J O, Schepers K, Braat A K, Hsiao E C, Barruet E, Morales B M, Verhaar M C, Rosenberg A J W P, Gawlitta D 16 jan 2019, In: Journal of Tissue Engineering and Regenerative Medicine. 13 , p. 433-445 13 p.