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prof. dr. ir. E.P.J.G. (Edwin) Cuppen

Full Professor
prof. dr. ir. E.P.J.G. (Edwin) Cuppen
  • Center for Molecular Medicine
  • Group Cuppen, section Genetics

Research Programs

Strategic Program Cancer

Biography

Biography

Edwin Cuppen is scientific director of the Hartwig Medical Foundation, a not-for-profit organisation that aims to improve cancer care by systematic whole genome sequencing analysis of tumors. Edwin is also professor of Human Genetics at the Center for Molecular Medicine of the University Medical Center in Utrecht and invited member of the virtual national cancer research organisation Oncode Institute. After his undergraduate and PhD training at Wageningen University and Radboud University Nijmegen as a molecular geneticist, he held research and group leader positions at the Netherlands Cancer Institute and the Hubrecht Institute. His current research focuses on understanding the causes and consequences of de novo genetic variation, specifically in relation to cancer, by using systematic genomics and data integration approaches.

Side Activities

  • Academic advisory activities

    Member 'wetenschappelijke raad KiKa' (scientific council foundation Children Cancer Free) (not remunerated)

    Scientific Advisory Board InteRNA Technologies BV (miRNA-based therapeutics) (personal remuneration)

    Advisory Board Clinical Whole Genome Sequencing Illumina (remeration transfered to employer)

    Employment at other organisation

    Scientific Director Hartwig Medical Foundation

Fellowship and Awards

  • European Young Investigator Award 2005

    NWO Vici grant 2013

Research Output (349)

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Verstegen Monique M A, Roos Floris J M, Burka Ksenia, Gehart Helmuth, Jager Myrthe, de Wolf Maaike, Bijvelds Marcel J C, de Jonge Hugo R, Ardisasmita Arif I, van Huizen Nick A, Roest Henk P, de Jonge Jeroen, Koch Michael, Pampaloni Francesco, Fuchs Sabine A, Schene Imre F, Luider Theo M, van der Doef Hubert P J, Bodewes Frank A J A, de Kleine Ruben H J, Spee Bart, Kremers Gert-Jan, Clevers Hans, IJzermans Jan N M, Cuppen Edwin, van der Laan Luc J W 14 dec 2020, In: Scientific Reports. 10 , p. 21900 1 p.

Pan-cancer landscape of homologous recombination deficiency

Nguyen Luan, W M Martens John, Van Hoeck Arne, Cuppen Edwin 1 dec 2020, In: Nature Communications. 11 , p. 5584

Single-cell derived tumor organoids display diversity in HLA class I peptide presentation

Demmers Laura C, Kretzschmar Kai, Van Hoeck Arne, Bar-Epraïm Yotam E, van den Toorn Henk W P, Koomen Mandy, van Son Gijs, van Gorp Joost, Pronk Apollo, Smakman Niels, Cuppen Edwin, Clevers Hans, Heck Albert J R, Wu Wei 1 dec 2020, In: Nature Communications. 11 , p. 5338

Publisher Correction:The mutational impact of culturing human pluripotent and adult stem cells

Kuijk Ewart, Jager Myrthe, van der Roest Bastiaan, Locati Mauro D, Van Hoeck Arne, Korzelius Jerome, Janssen Roel, Besselink Nicolle, Boymans Sander, van Boxtel Ruben, Cuppen Edwin 1 dec 2020, In: Nature Communications. 11 , p. 3932

The mutational impact of culturing human pluripotent and adult stem cells

Kuijk Ewart, Jager Myrthe, van der Roest Bastiaan, Locati Mauro D, Van Hoeck Arne, Korzelius Jerome, Janssen Roel, Besselink Nicolle, Boymans Sander, van Boxtel Ruben, Cuppen Edwin 1 dec 2020, In: Nature Communications. 11 12 p.

Study protocol:Whole genome sequencing Implementation in standard Diagnostics for Every cancer patient (WIDE)

Samsom Kris G, Bosch Linda J W, Schipper Luuk J, Roepman Paul, de Bruijn Ewart, Hoes Louisa R, Riethorst Immy, Schoenmaker Lieke, van der Kolk Lizet E, Retèl Valesca P, Frederix Geert W J, Buffart Tineke E, van der Hoeven Jacobus J M, Voest Emile E, Cuppen Edwin, Monkhorst Kim, Meijer Gerrit A dec 2020, In: BMC Medical Genomics [E]. 13 , p. 169

Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

de Witte Chris Jenske, Espejo Valle-Inclan Jose, Hami Nizar, Lõhmussaar Kadi, Kopper Oded, Vreuls Celien Philomena Henrieke, Jonges Geertruida Nellie, van Diest Paul, Nguyen Luan, Clevers Hans, Kloosterman Wigard Pieter, Cuppen Edwin, Snippert Hugo Johannes Gerhardus, Zweemer Ronald Peter, Witteveen Petronella Oda, Stelloo Ellen 16 jun 2020, In: Cell Reports. 31 8 p.

Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine

Dijkstra Krijn K, Monkhorst Kim, Schipper Luuk J, Hartemink Koen J, Smit Egbert F, Kaing Sovann, de Groot Rosa, Wolkers Monika C, Clevers Hans, Cuppen Edwin, Voest Emile E 5 mei 2020, In: Cell Reports. 31 12 p.

SARS-CoV-2 productively infects human gut enterocytes

Lamers Mart M, Beumer Joep, van der Vaart Jelte, Knoops Kèvin, Puschhof Jens, Breugem Tim I, Ravelli Raimond B G, Paul van Schayck J, Mykytyn Anna Z, Duimel Hans Q, van Donselaar Elly, Riesebosch Samra, Kuijpers Helma J H, Schippers Debby, van de Wetering Willine J, de Graaf Miranda, Koopmans Marion, Cuppen Edwin, Peters Peter J, Haagmans Bart L, Clevers Hans 1 mei 2020, In: Science. 369 , p. 50-54 5 p.

Sperm DNA damage causes genomic instability in early embryonic development

Middelkamp Sjors, van Tol Helena T A, Spierings Diana C J, Boymans Sander, Guryev Victor, Roelen Bernard A J, Lansdorp Peter M, Cuppen Edwin, Kuijk Ewart W apr 2020, In: Science advances. 6

All research output