prof. dr. O.L. (Olaf) Cremer

Full Professor

  • Intensive Care Medicine

prof. dr. O.L. (Olaf) Cremer

Research Programs


Olaf Cremer (1971) was trained as an anesthesiologist, intensivist and clinical epidemiologist. He has worked as a consultant in the department of intensive care medicine of the UMCU since 2007. Dr. Cremer has designed and co-developed the patient data management system that is currently in use. His detailed knowledge of the system and computer programming skills allow him to explore this clinical database as a rich source of information for several research projects within the division.
Prof. Cremer obtained his PhD degree in 2005 with a doctoral thesis on goal-directed management of patients with severe traumatic brain injury. His thesis included both experimental clinical studies focused on cerebrovascular pathophysiology, as well as large cohort studies focused on patient outcomes. Since 2010 he has been studying the clinical epidemiology of infections in the ICU and/or the postoperative setting. He is one of the PI's of the MARS consortium, a multicentre collaboration aimed at developing new molecular technologies for early diagnosis and risk stratification of sepsis. More recently he initiated the PLUTO project, a longitudinal biorepository of patients undergoing elective surgery in the UMCU. The main focus areas of his research group include:

1 - diagnostic uncertainty in early detection of sepsis

2 - attributable morbidity and mortality of (nosocomial) sepsis and acute inflammation

3 - decision support for diagnosis and treatment of sepsis

Cremer has been mentoring 11 PhD students to date.

Research Output (176)

A Higher Fluid Balance in the Days After Septic Shock Reversal Is Associated With Increased Mortality:An Observational Cohort Study

van Mourik Niels, Geerts Bart F, Binnekade Jan M, Veelo Denise P, Bos Lieuwe D J, Wiersinga W Joost, van der Poll Tom, Cremer Olaf L, Schultz Marcus J, Vlaar Alexander P J okt 2020, In: Critical care explorations. 2 , p. e0219

Cytomegalovirus reactivations in the critically ill

Ong D. S. Y., Cremer O. L. sep 2020, In: Netherlands Journal of Critical Care. 28 , p. 194-199

Elevated trefoil factor 3 plasma levels in critically ill patients with abdominal sepsis or non-infectious abdominal illness

Meijer Mariska T, Uhel Fabrice, Cremer Olaf L, Scicluna Brendon P, Schultz Marcus J, van der Poll Tom, 27 jun 2020, In: Cytokine. 133 5 p.

Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis:a prospective cohort study

Uhel Fabrice, Peters-Sengers Hessel, Falahi Fahimeh, Scicluna Brendon P, van Vught Lonneke A, Bonten Marc J, Cremer Olaf L, Schultz Marcus J, van der Poll Tom, 8 jun 2020, In: Intensive Care Medicine. 46 , p. 1576-1589 14 p.

Occurrence and Risk Factors of Chronic Pain After Critical Illness

Koster-Brouwer Maria E., Rijsdijk Mienke, Van Os Wouter K.M., Soliman Ivo W., Slooter Arjen J.C., De Lange Dylan W., Van Dijk Diederik, Bonten Marc J.M., Cremer Olaf L. 10 feb 2020, In: Critical Care Medicine. 48 , p. 680-687 8 p.

Correction to:Predicting the clinical trajectory in critically ill patients with sepsis: a cohort study

Klein Klouwenberg Peter M C, Spitoni Cristian, van der Poll Tom, Bonten Marc J, Cremer Olaf L, 6 feb 2020, In: Critical care (London, England). 24

Potential of Parameters of Iron Metabolism for the Diagnosis of Anemia of Inflammation in the Critically Ill

Boshuizen Margit, Binnekade Jan M, Nota Benjamin, van de Groep Kirsten, Cremer Olaf L, Horn Janneke, Schultz Marcus J, van Bruggen Robin, Juffermans Nicole P feb 2020, In: Transfusion Medicine and Hemotherapy. 47 , p. 61-67 7 p.

The hemodynamic effect of different left ventricular unloading techniques during veno-arterial extracorporeal life support:a systematic review and meta-analysis

Meuwese Christiaan Lucas, de Haan Marloes, Zwetsloot Peter-Paul, Braithwaite Sue, Ramjankhan Faiz, van der Heijden Joris, Hermens Jeannine, Cremer Olaf, Broomé Michael, Donker Dirk Wilhelm 17 jan 2020, In: Perfusion. 35 , p. 664-671 8 p.

The Diagnostic Yield of Routine Admission Blood Cultures in Critically Ill Patients

Verboom Diana M, van de Groep Kirsten, Boel C H Edwin, Haas Pieter Jan A, Derde Lennie P G, Cremer Olaf L, Bonten Marc J M 2020, In: Critical care medicine. 49 , p. 60-69 10 p.

Preemptive Treatment of Herpes Simplex Virus Reactivation in Critically Ill Patients?-Not Based on Current Data

Ong David S Y, Cremer Olaf L, Bonten Marc J M 16 dec 2019, In: JAMA Internal Medicine. 180 , p. 272-273 2 p.

All Research Output (176)